BMC Medical Genomics · 2020

Improving lung cancer risk stratification leveraging whole transcriptome RNA sequencing and machine learning across multiple cohorts

Yoonha Choi, Jianghan Qu, Shuyang Wu, Yangyang Hao, Jiarui Zhang, Jianchang Ning, Xinwu Yang, Lori Lofaro, Daniel G. Pankratz, Joshua Babiarz, P. Sean Walsh, Ehab Billatos, Marc E. Lenburg, Giulia C. Kennedy, Jon McAuliffe, Jing Huang

Journal
BMC Medical Genomics · vol. 13 · no. Suppl 10 · pp. 151
Published
22 Oct 2020

Synopsis

The development paper for the RNA sequencing-based Percepta Genomic Sequencing Classifier, built with ensemble and hierarchical models across multiple cohorts. The final GSC model uses 1,232 genes and four clinical covariates: age, pack-years, inhaled medication use and specimen collection timing. Kennedy is fourteenth of sixteen authors.

In the career genome

  • VeracyteChapter 09 · Strand B · Research
    Veracyte, Inc.

    Percepta and Envisia

    Chief Scientific Officer and Chief Medical Officer, Veracyte

    APR 2015 – APR 2024