Giulia KennedyPhD
Nature Genetics · 1995

The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription

Giulia Catignani Kennedy, Michael S. German, William J. Rutter

First authorverifiedGene regulation and gene discovery
Journal
Nature Genetics · vol. 9 · no. 3 · pp. 293-298
Published
Mar 1995

Synopsis

Showed that the insulin-linked polymorphic region (ILPR), the minisatellite at the type 1 diabetes susceptibility locus IDDM2, is capable of transducing a transcriptional signal in pancreatic beta cells, with a long ILPR possessing greater activity than a short one. The finding is cited in the OMIM entry for type 1 diabetes mellitus 2 as the mechanistic link between the insulin VNTR and disease susceptibility.

In the career genome

  • UCSFChapter 01 · Strand A · Institution
    University of California, San Francisco

    Education and training

    B.S. Applied Science; Ph.D. Biochemistry; postdoctoral training in biochemistry

    1992 – 1995